N-Iodosuccinimide → 4-(3-Iodo-1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one

HRID 2234094Notes

Reaction equation

HRID 2234094 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]1[C:11](=[O:22])[NH:12][N:13]=[C:14]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH:15]=1.C1C(=O)N([I:30])C(=O)C1>CC(C)=O>[I:30][C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]=1[C:10]1[C:11](=[O:22])[NH:12][N:13]=[C:14]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH:15]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 1356875534-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one

Product 1

HCID 1354144544-(3-Iodo-1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

577 mg 4-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one is suspended in 30 mL acetone and 550 mg NIS is added. The reaction mixture is stirred for 3 hours at room temperature, the precipitated product isolated by filtration and washed with aceton. The material product is used without further purification

Workup

  1. customthe precipitated product isolated by filtration
  2. washwashed with aceton
  3. customThe material product is used without further purification

Sources & evidence

ORD record
ord-8e27401db6f44d2197b3671e7605c53d
Source dataset
uspto-grants-2010_05
Patent number
US07709466B2

Reaction notes

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