HCID 68637501, compound → HCID 68636060, compound

HRID 2234103Notes

Reaction equation

HRID 2234103 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[N:5][C:6]([C:23]2[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=2)=[CH:7][C:8]=1[C:9]1[NH:10][C:11]2[C:16]([C:17]=1[CH:18]=[CH:19][CH2:20][CH2:21][CH3:22])=[CH:15][CH:14]=[CH:13][CH:12]=2>[Pd].C(O)C>[CH3:1][O:2][C:3]1[N:4]=[N:5][C:6]([C:23]2[CH:24]=[CH:25][N:26]=[CH:27][CH:28]=2)=[CH:7][C:8]=1[C:9]1[NH:10][C:11]2[C:16]([C:17]=1[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:15][CH:14]=[CH:13][CH:12]=2

Participants

4

Reactant 1

HCID 68637501HCID 68637501, compound

Product 1

HCID 68636060HCID 68636060, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

20 mg Palladium catalyst (10% on Charcoal) is added to a solution of 145 mg 2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-3-pent-1-enyl-1H-indole in 1 ml ethanol and the suspension is stirred under a hydrogen atmosphere for 8 hours. The crude product is isolated by filtration and removal of the solvent and purified by silicagel chromatography (ethylacetate/n-hepatane)

Sources & evidence

ORD record
ord-2d622908c74144a0875bf8d68ca5eb2a
Source dataset
uspto-grants-2010_05
Patent number
US07709466B2

Reaction notes

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