Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 68638614 | HCID 68638614 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 135961907 | HCID 135961907 | 59.8% |
Reaction Steps
62 mg 2-(3-Methoxy-6-pyridin-4-yl-pyridazin-4-yl)-3-phenyl-6-piperidin-1-ylmethyl-1H-indole are dissolved in 0.5 mL ethanol. 0.75 mL 1 N aqueous sodium hydroxide are added. The reaction mixture is heated to 150° C. in a microwave oven for 15 minutes. Purification by HPLC affords 36 mg (58%) 4-(3-phenyl-6-piperidin-1-ylmethyl-1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one as its trifluoro-acetate salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07709466B2 |
|---|
| Source dataset | uspto-grants-2010_05 |
|---|
| ORD ID | ord-7dc1e9b706874d049df6086a10640cb1 |
|---|
| Source note | uspto-grants-2010_05 |
|---|
