HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 135961807, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 68637574 | HCID 68637574 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 135961807 | HCID 135961807 | — |
Reaction Steps
2-[3-Methoxy-6-(1-methyl-1H-pyrazol-4-yl)-pyridazin-4-yl]-indole-1-carboxylic acid tert-butyl ester is dissolved in 8 ml dioxan and 8 ml aqueous 2N NaOH and heated by microwave irradiation for 90 min at 150° C. The solution is neutralized with aqueous HCl and the product is purified by preparative RP-HPLC eluting with a gradient of 0-100% acetonitrile in water (+0.01% trifluoroacetic acid). Yield 35 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709466B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-9c1ceb9284484287b6ceb4cabbc03fbf |
| Source note | uspto-grants-2010_05 |