N-bromobutanimide → 3-Bromo-2-(6-chloro-3-methoxy-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester

HRID 2234112Notes

Reaction equation

HRID 2234112 reaction equation
[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[C:9]1[C:17]1[CH:22]=[C:21]([Cl:23])[N:20]=[N:19][C:18]=1[O:24][CH3:25])=[O:7])([CH3:4])([CH3:3])[CH3:2].[Br:26]N1C(=O)CCC1=O>>[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([Br:26])=[C:9]1[C:17]1[CH:22]=[C:21]([Cl:23])[N:20]=[N:19][C:18]=1[O:24][CH3:25])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 866120482-(6-Chloro-3-methoxy-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester

Product 1

HCID 866120563-Bromo-2-(6-chloro-3-methoxy-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester

Procedure

100 mg of 2-(6-chloro-3-methoxy-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester is dissolved in 5 ml dimethoxythane and 75 mg of N-bromosuccinimide is added. The solution is stirred at RT for 16 h. The resulting solution is used in the subsequent reaction without further purification.

Workup

  1. additionis added
  2. customThe resulting solution is used in the subsequent reaction without further purification

Sources & evidence

ORD record
ord-670699f21a834a7fae5c27a1de1630ec
Source dataset
uspto-grants-2010_05
Patent number
US07709466B2

Reaction notes

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