HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2234114Generated: November 1, 2026
Sodium Hydroxide → 4-(6-bromo-1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one
https://huagongshe.com/reaction/2234114
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 6-Bromo-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester | HCID 68637361 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(6-bromo-1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one | HCID 135961872 | 65.5% |
Reaction Steps
40 mg 6-Bromo-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester are dissolved in 0.5 mL ethanol. 0.58 mL 1 N aqueous sodium hydroxide are added. The reaction mixture is heated to 150° C. in a microwave oven for 15 minutes. Purification by HPLC affords 20 mg (50%) 4-(6-bromo-1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07709466B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-bdd6648f80ed49ac8fb65514e54e939a |
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| Source note | uspto-grants-2010_05 |
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