N-bromobutanimide → HCID 135961877, compound

HRID 2234118Notes

Reaction equation

HRID 2234118 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]1[C:11](=[O:22])[NH:12][N:13]=[C:14]([C:16]2[CH:17]=[N:18][N:19]([CH3:21])[CH:20]=2)[CH:15]=1.[Br:23]N1C(=O)CCC1=O>CC(C)=O>[Br:23][C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]=1[C:10]1[C:11](=[O:22])[NH:12][N:13]=[C:14]([C:16]2[CH:17]=[N:18][N:19]([CH3:21])[CH:20]=2)[CH:15]=1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 135961807HCID 135961807, compound

Product 1

HCID 135961877HCID 135961877, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

30 mg of 4-(1H-Indol-2-yl)-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one is dissolved in 4 ml of acetone and 22 mg of N-bromosuccinimide is added. The solution is stirred at RT for 20 min and the product is purified by preparative RP-HPLC eluting with a gradient of 0-100% acetonitrile in water (+0.01% trifluoroacetic acid). Yield 14 mg. LC-MS (ES+) 370/372 (M+H)+.

Workup

  1. customthe product is purified by preparative RP-HPLC
  2. washeluting with a gradient of 0-100% acetonitrile in water (+0.01% trifluoroacetic acid)

Sources & evidence

ORD record
ord-b1bf1d03242d46f2bde966a3211ab5c1
Source dataset
uspto-grants-2010_05
Patent number
US07709466B2

Reaction notes

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