HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2234120Generated: November 2, 2026
Sodium Hydroxide → 4, N-dimethyl-N-[2-(3-oxo-6-pyridin-4-yl-2,3-dihydro-pyridazin-4-yl)-1H-indol-6-yl]-benzenesulfonamide
https://huagongshe.com/reaction/2234120
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(3-Methoxy-6-pyridin-4-yl-pyridazin-4-yl)-6-[methyl-(toluene-4-sulfonyl)-amino]-indole-1-carboxylic acid tert-butyl ester | HCID 68637032 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4, N-dimethyl-N-[2-(3-oxo-6-pyridin-4-yl-2,3-dihydro-pyridazin-4-yl)-1H-indol-6-yl]-benzenesulfonamide | HCID 135961839 | 48.9% |
Reaction Steps
155 mg 2-(3-Methoxy-6-pyridin-4-yl-pyridazin-4-yl)-6-[methyl-(toluene-4-sulfonyl)-amino]-indole-1-carboxylic acid tert-butyl ester are dissolved in 2.25 mL ethanol. 1.85 mL 1 N aqueous sodium hydroxide are added. The reaction mixture is heated to 150° C. in a microwave oven for 15 minutes. Purification by HPLC affords 61 mg (39%) 4, N-dimethyl-N-[2-(3-oxo-6-pyridin-4-yl-2,3-dihydro-pyridazin-4-yl)-1H-indol-6-yl]-benzenesulfonamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07709466B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-69c49b86b2154162bf27defaa94530c7 |
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| Source note | uspto-grants-2010_05 |
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