Sodium Hydroxide → HCID 135487387, compound

HRID 2234125Notes

Reaction equation

C([C:4]1[C:12]2[C:7](=[CH:8][C:9]([CH2:13][N:14]3[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]3)=[CH:10][CH:11]=2)[NH:6][C:5]=1[C:21]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)[N:24]=[N:23][C:22]=1OC)(C)C.[OH-:35].[Na+]>C(O)C>[CH2:8]([C:4]1[C:12]2[C:7](=[CH:8][C:9]([CH2:13][N:14]3[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]3)=[CH:10][CH:11]=2)[NH:6][C:5]=1[C:21]1[C:22](=[O:35])[NH:23][N:24]=[C:25]([C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)[CH:26]=1)[CH:9]([CH3:13])[CH3:10]

Participants

Conditions

Temperature: 150 °C

Procedure

98 mg 3-Isopropyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-6-(4-methyl-piperazin-1-ylmethyl)-1H-indole are dissolved in 1.23 mL ethanol. 1.18 mL 1 N aqueous sodium hydroxide are added. The reaction mixture is heated to 150° C. in a microwave oven for 15 minutes. Purification by HPLC affords 39 mg (41%) 4-[3-isobutyl-6-(4-methyl-piperazin-1-ylmethyl)-1H-indol-2-yl]-6-pyridin-4-yl-2H-pyridazin-3-one as its trifluoroacetate salt.

Workup

customPurification by HPLC

Sources & evidence

ORD record: ord-9dcd63fd797d4e43b2f6f53289fd8ddc
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07709466B2

Reaction notes

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