HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-Chloro-4-(1H-indol-2-yl)-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-(6-Chloro-3-methoxy-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester | HCID 86612048 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 6-Chloro-4-(1H-indol-2-yl)-2H-pyridazin-3-one | HCID 135961886 | — |
Reaction Steps
2 g of 2-(6-chloro-3-methoxy-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester is treated for 16 h at 85° C. with 2.76 g of KI and 1.8 g of trimethylsilylchloride in 200 ml acetonitrile. On completion of the reaction the reaction solution is poured into water and the precipitated product is isolated by filtration. Yield: 1.33 g. LC-MS (ES+) 246 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709466B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-0c27febd4b234755a93476f8fe43ac2d |
| Source note | uspto-grants-2010_05 |