Potassium Iodide → HCID 135961826, compound

Participants

Reaction Steps

100 mg crude 3-benzyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-6-(4-methyl-pi-perazin-1-ylmethyl)-1H-indole are dissolved in 2.4 mL acetonitrile. 75 □L TMSCl and 99 mg potassium iodide are added. The reaction mixture is heated to reflux for 3 hours. Then again 75 □L TMSCl and 99 mg potassium iodide are added and the reaction mixture is refluxed for additional 2 hours. Purification by HPLC affords 31 mg (32%) 4-[3-benzyl-6-(4-methyl-piperazin-1-ylmethyl)-1H-indol-2-yl]-6-pyridin-4-yl-2H-pyridazin-3-one as its trifluoroacetate salt.

Provenance & Evidence