Triacetoxyperiodinane → HCID 68637014, compound

Participants

Reaction Steps

200 mg Dess-Martin periodinane (1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one) is added to a solution of 210 mg 6-(1-hydroxy-ethyl)-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butylester (145a) in 4 ml dichloromethane and the mixture stirred for 2.5 hours at room temperature. Than the solution is extracted with a 5% Na2SO3 solution and water, dried using a silicagel cartridge and the solvent removed in vacuo. The crude product is purified by chromatography on silica gel (heptane/ethylacetate)

Provenance & Evidence