2,4-di(tert-butoxy)pyrimidin-5-ylboronic acid hydrate → HCID 136367321, compound

HRID 2234133Notes

Reaction equation

HRID 2234133 reaction equation
Br[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:11]1[CH:12]=[C:13]([C:19]2[CH:24]=[C:23]([CH3:25])[C:22]([OH:26])=[C:21]([CH3:27])[CH:20]=2)[N:14]=[N:15][C:16]=1[O:17][CH3:18].O.C([O:33][C:34]1[N:39]=[C:38]([O:40]C(C)(C)C)[C:37](B(O)O)=[CH:36][N:35]=1)(C)(C)C>>[OH:26][C:22]1[C:23]([CH3:25])=[CH:24][C:19]([C:13]2[N:14]=[N:15][C:16]([O:17][CH3:18])=[C:11]([C:3]3[NH:4][C:5]4[C:10]([C:2]=3[C:37]3[C:38](=[O:40])[NH:39][C:34](=[O:33])[NH:35][CH:36]=3)=[CH:9][CH:8]=[CH:7][CH:6]=4)[CH:12]=2)=[CH:20][C:21]=1[CH3:27]

Participants

3

Reactant 2

HCID 27359492,4-di(tert-butoxy)pyrimidin-5-ylboronic acid hydrateHCID 136367322HCID 136367322, compound

Product 1

HCID 136367321HCID 136367321, compound

Procedure

111 mg of 4-[5-(3-bromo-1H-indol-2-yl)-6-methoxy-pyridazin-3-yl]-2,6-dimethyl-phenol is treated analogously to example 6 (c), using 2,4-di(tert-butoxy)pyrimidin-5-yl boronic acid hydrate. Yield 100 mg. LC-MS (ES+) 455 (M+H)+.

Sources & evidence

ORD record
ord-88fdc3fd3fd94c049c05976d3c4777b6
Source dataset
uspto-grants-2010_05
Patent number
US07709466B2

Reaction notes

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