Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | HCID 68637619 | HCID 68637619 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 135961887 | HCID 135961887 | — |
Reaction Steps
18 mg of 2-[6-(3-hydroxymethyl-5-methylaminomethyl-phenyl)-3-methoxy-pyridazin-4-yl]-indole-1-carboxylic acid tert-butyl ester is dissolved in 3 ml of acetonitrile and 19 mg of potassium iodide and 12 mg of chlorotrimethylsilane are added. The reaction is heated to 85° C. for 5 h. The reaction is quenched by the addition of a drop of water, the solvent is removed under reduced pressure and the product is purified by preparative RP-HPLC eluting with a gradient of 0-100% acetonitrile in water (+0.01% trifluoroacetic acid). Yield 3.5 mg. LC-MS (ES+) 361 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07709466B2 |
|---|
| Source dataset | uspto-grants-2010_05 |
|---|
| ORD ID | ord-16bc6e78ff7241d1bf3f44920799e024 |
|---|
| Source note | uspto-grants-2010_05 |
|---|
