HRID2234139

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1nnc(Cl)cc1-c1cc2ccccc2n1C(=O)OC(C)(C)C

HCID86612048

未命名化合物

结构：COc1cc(B2OC(C)(C)C(C)(C)O2)cc(C=O)c1OCOCC[Si](C)(C)C

HCID86612061

未命名化合物

PRODUCTS

生成物

结构：COc1cc(-c2cc(-c3cc4ccccc4n3C(=O)OC(C)(C)C)c(OC)nn2)cc(C=O)c1OCOCC[Si](C)(C)C

HCID86612060

未命名化合物

PROCEDURE

实验过程

400 mg of 3-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2-(2-trimethylsilanyl-ethoxymethoxy)-benzaldehyde and 353 mg of 2-(6-Chloro-3-methoxy-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester is reacted analogously to the procedure described in Example 126(a). Yield 377 mg. LC-MS (ES+) 606 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-230e016a2eb9462d893e94df0d44072d
来源数据集: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07709466B2
来源说明: uspto-grants-2010_05

反应 SMILES

[CH3:1][O:2][C:3]1[C:4]([O:20][CH2:21][O:22][CH2:23][CH2:24][Si:25]([CH3:28])([CH3:27])[CH3:26])=[C:5]([CH:8]=[C:9](B2OC(C)(C)C(C)(C)O2)[CH:10]=1)[CH:6]=[O:7].[C:29]([O:33][C:34]([N:36]1[C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[CH:38]=[C:37]1[C:45]1[CH:50]=[C:49](Cl)[N:48]=[N:47][C:46]=1[O:52][CH3:53])=[O:35])([CH3:32])([CH3:31])[CH3:30]>>[C:29]([O:33][C:34]([N:36]1[C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[CH:38]=[C:37]1[C:45]1[CH:50]=[C:49]([C:9]2[CH:10]=[C:3]([O:2][CH3:1])[C:4]([O:20][CH2:21][O:22][CH2:23][CH2:24][Si:25]([CH3:26])([CH3:27])[CH3:28])=[C:5]([CH:6]=[O:7])[CH:8]=2)[N:48]=[N:47][C:46]=1[O:52][CH3:53])=[O:35])([CH3:32])([CH3:31])[CH3:30]