Hydrochloric Acid → HCID 86258401, compound

Participants

Reaction Steps

N-(2,2-Diethoxyethyl)-3-phenethyloxy-N-(3-pyridylmethyl)propanamide (Example 5a), 0.086 g) was dissolved in anhydrous dioxane (3 mL) and treated with concentrated hydrochloric acid (0.6 mL) at ambient temperature. The resultant solution was stirred at ambient temperature for 2.5 hours. The reaction mixture was then poured into dichloromethane (10 mL) and basified with saturated sodium bicarbonate. The organic layer was isolated, washed with water (2×10 mL), washed with brine (10 mL), dried over anhydrous magnesium sulphate, filtered and concentrated to give the sub-titled compound that was used in the next step without further purification.

Provenance & Evidence