反应详情

温度

0 °C

2-(4-Bromophenyl)ethanol (5 g) was treated with benzyltrimethylammonium hydroxide (Triton B®) (0.3 mL) and the resultant mixture was stirred in vacuo for 30 minutes. The mixture was then cooled to 0° C. and treated with t-butyl acrylate (3.5 g). The reaction was warmed to room temperature and stirred for 5 hours. The mixture was filtered through aluminium oxide (15 g) eluting with ether (75 mL). The collected filtrate was concentrated and purified by flash chromatography eluting with ethylacetate:iso-hexane (1:8) to give the sub-titled compound (5.42 g) as an oil.

1. temperatureThe reaction was warmed to room temperature
2. filtrationThe mixture was filtered through aluminium oxide (15 g)
3. washeluting with ether (75 mL)
4. concentrationThe collected filtrate was concentrated
5. custompurified by flash chromatography
6. washeluting with ethylacetate:iso-hexane (1:8)