Dimethylformamide → HCID 14277601, compound

Participants

Reaction Conditions

Reaction Steps

To N,N-dimethylformamide (20 ml) were added thiourea (0.76 g), zinc powder (0.5 g) and a solution of ammonium chloride (0.67 g) in water (3 ml). To the mixture was added benzhydryl 7-phenylacetamido-3-chloromethyl-3-cephem-4-carboxylate (2.67 g) under cooling to -15° C. with stirring, and the mixture was stirred for an hour at -15° to -10° C., and then filtered. To the filtrate were added ethyl acetate (100 ml) and water (100 ml), and the organic layer was separated therefrom. The organic layer was washed with water, dried over magnesium sulfate and then concentrated under reduced pressure. The residue was pulverized with diisopropyl ether to give benzhydryl 7-phenylacetamido-3-methylenecepham-4-carboxylate (2.2 g).

Provenance & Evidence