HCID 68705258, compound → HCID 68707006, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 21 part f) was suspended in 48% aq HBr (1 ml) and heated in a microwave at 100° C. for 30 min. The resulting solution was evaporated, azeotroped with ethanol (×2) to give a residue which solidified on standing. The solid was triturated with acetonitrile and the white solid collected by filtration which was further purified by reverse phase HPLC. The desired product fractions were evaporated in vacuo, the residue dissolved in ethanol and conc. Aq. HBr (1 ml) was added. This solution was evaporated in vacuo and the residue azeotroped with ethanol (×5). The resulting solid was triturated with ethanol and collected by filtration to give the title compound as a white solid (10 mg).

Provenance & Evidence