HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 2,3-dihydro-7-methoxy-8-[3-(4-phenyl-1-piperidinyl)propoxy]cyclopenta[c][1]benzopyran-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 2,3-dihydro-8-[3-(methanesulfonyloxy)propoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one | HCID 19927662 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,3-dihydro-7-methoxy-8-[3-(4-phenyl-1-piperidinyl)propoxy]cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927646 | 65% |
Reaction Steps
Method B (60 h at 25° C.); starting materials: 2,3-dihydro-8-[3-(methanesulfonyloxy)propoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one (example 82) and 4-phenylpiperidine; yield 65%; fusion point 164°-166° C. (from isopropanol). Fumarate: method E; yield 86%; fusion point 195°-198° C. (from ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-dba128891fca4621af94e618a5af991d |
| Source note | uspto-grants-1995_06 |