Trifluoroacetic acid → HCID 68698368, compound

Participants

Reaction Steps

tert-Butyl 3-[2-(2-naphthyl)ethoxy]propanoate (Example 32a) (4.96 g) was dissolved in DCM (25 ml), and trifluoroacetic acid (25.5 ml) added. The mixture was stirred for 1 hour. The solvents were removed in vacuo, and the residue taken up in ether. The ether was washed with saturated bicarbonate solution (×3) and the aqueous layer was acidified with 2N HCl, then extracted with ether (×3), dried over magnesium sulfate, filtered and evaporated to give the sub-titled compound (3.66 g).

Provenance & Evidence