反应详情

温度

110 °C

tBuOK (16.8 g) is added to a solution of (R)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine (31 g) in DMSO (100 ml), bubbled with a moderate stream of nitrogen, and the mixture is stirred and heated at 110° C. for 2 hours. After cooling down to lab temperature, the mixture is diluted with water (300 ml) and the racemic product is extracted with toluene. After evaporation, 25 g (84%) of (RS)-N-methyl-3-(naphthyloxy)-3-(2-thienyl)propylamine is obtained.

1. custombubbled with a moderate stream of nitrogen
2. temperatureAfter cooling down to lab temperature
3. additionthe mixture is diluted with water (300 ml)
4. extractionthe racemic product is extracted with toluene
5. customAfter evaporation