HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2234314Generated: November 1, 2026
p-Toluenesulfonic acid monohydrate → HCID 25123685, compound
https://huagongshe.com/reaction/2234314
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 2-Chloro-9-cyclopentyl-7,7-dimethyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one | HCID 58154012 | — |
| Reactant | HCID 68684708 | HCID 68684708 | — |
| Solvent | 4-Methyl-2-Pentanol | HCID 7910 | — |
| Product | HCID 25123685 | HCID 25123685 | — |
Reaction Steps
10-chloro-2-cyclopentyl-4,4-dimethyl-2,6,9,11-tetrazabicyclo[5.4.0]undeca-8,10,12-trien-5-one (Intermediate 127; 50 mg, 0.16 mmol) and tert-butyl 4-[(4-amino-3-methoxy-benzoyl)amino]piperidine-1-carboxylate (Intermediate 234; 85 mg, 0.24 mmol) were dissolved in 4-methyl-2-pentanol (1 mL) and p-toluenesulphonic acid monohydrate (44 mg, 0.32 mmol) added. The reaction mixture was heated at 90° C. by microwave irradiation for 20 minutes and then at 150° C. for a further 45 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07709471B2 |
|---|
| Source dataset | uspto-grants-2010_05 |
|---|
| ORD ID | ord-5aecb5902e724282bc2bae75a21e7020 |
|---|
| Source note | uspto-grants-2010_05 |
|---|
