HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-2-Pentanol → HCID 25127325, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-2-Pentanol | HCID 7910 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 4-amino-N-(1-ethyl-4-piperidyl)-3-methoxy-benzamide | HCID 58015093 | — |
| Reactant | 2-Chloro-9-cyclopentyl-7,7-dimethyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one | HCID 58154012 | — |
| Product | HCID 25127325 | HCID 25127325 | — |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
10-chloro-2-cyclopentyl-4,4-dimethyl-2,6,9,11-tetrazabicyclo[5.4.0]undeca-8,10,12-trien-5-one (Intermediate 127; 115 mg, 0.37 mmol) and 4-amino-N-(1-ethyl-4-piperidyl)-3-methoxy-benzamide (Intermediate 190; 104 mg, 0.37 mmol) were dissolved 4-methyl-2-pentanol (3 mL). p-Toluenesulphonic acid monohydrate (142 mg, 0.74 mmol) was added and mixture heated by microwave irradiation at 160° C. for 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709471B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-55d835f475564fdca8ddedb98eefd828 |
| Source note | uspto-grants-2010_05 |