HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 68683795, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 68683735 | HCID 68683735 | — |
| Product | HCID 68683795 | HCID 68683795 | — |
Reaction Steps
4-[(2-cyclopentyl-4,4,6-trimethyl-5-oxo-2,6,9,11-tetrazabicyclo[5.4.0]undeca-7,9,11-trien-10-yl)amino]-3-chloro-benzoic acid (Intermediate 253; 52 mg, 0.12 mmol) was suspended in DMF (4 mL). DIPEA (62 ul, 0.35 mmol) was added to give a straw coloured solution. Endo-9-methyl-9-azabicyclo[3,3,1]-nonan-3-amine (Chempacific; 26 mg, 0.16 mmol) was added, followed by HATU (67 mg, 0.17 mmol) and the resultant mixture was stirred at ambient temperature overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709471B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-5245105eda834888a4978d56431fd799 |
| Source note | uspto-grants-2010_05 |