2-chloro-9-cyclopentyl-8,9-dihydro-5-methylspiro[5H-pyrimido[4,5-b][1,4]diazepine-7,1'-cyclopropan]-6(7H)-one → 4-(9'-cyclopentyl-5'-methyl-6'-oxo-5',6',8',9'-tetrahydrospiro[cyclopropane-1,7'-pyrimido[5,4-b][1,4]diazepine]-2'-ylamino)-N-[(3R)-1-ethylpyrrolidin-3-yl]-3-methoxy-benzamide

Participants

Reaction Steps

The title compound was prepared by an analogous method to the preparation of Example 350, utilising, 2′-chloro-9′-cyclopentyl-5′-methyl-8′,9′-dihydrospiro[cyclopropane-1,7′-pyrimido[5,4-b][1,4]diazepin]-6′(5′H)-one (Intermediate 130; 75 mg, 0.24 mmol), and 4-amino-N-[(3R)-1-ethylpyrrolidin-3-yl]-3-methoxy-benzamide (Intermediate 245; 70 mg, 0.26 mmol) heating by microwave irradiation at 160° C. for 1 hour, as an off-white foam (50 mg, 39%).

Provenance & Evidence