反应详情

N-Methylacrylamide (851 mg, 10.00 mmol) and isopropylamine (1.71 mL, 1.18 g, 20.00 mmol) in MeOH (10 mL) were irradiated to 140° C. for 30 mins in a microwave reaction vessel. The reaction mixture was cooled and loaded onto a SCX-2 column and washed with MeOH (100 mL). The crude product was then eluted from the SCX-2 column with NH3 (100 mL, 7M in MeOH) and the volatiles removed under reduced pressure to afford the title compound (1.56 g, Quant.) as an oil, which was used without further purification.

1. temperatureThe reaction mixture was cooled
2. washwashed with MeOH (100 mL)
3. washThe crude product was then eluted from the SCX-2 column with NH3 (100 mL, 7M in MeOH)
4. customthe volatiles removed under reduced pressure