HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2234357Generated: October 25, 2026
2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide → 4-amino-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide
https://huagongshe.com/reaction/2234357
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide | HCID 67117746 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-amino-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide | HCID 66927285 | — |
Reaction Steps
2-fluoro-5-methoxy-N-(1-methyl-4-piperidyl)-4-nitro-benzamide Intermediate 28; 1.3 g, 4.2 mmol) 10% Palladium on Carbon (100 mg) and Methanol (50 mL) were combined and stirred at 25° C. under Hydrogen at 1 bar pressure for 18 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07709471B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-9ecb695237ea4969af047f347a4c79bc |
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| Source note | uspto-grants-2010_05 |
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