2,5-difluoro-N-(1-methyl-4-piperidyl)-4-nitro-benzamide → 4-amino-2,5-difluoro-N-(1-methyl-4-piperidyl)benzamide

HRID 2234376Notes

Reaction equation

HRID 2234376 reaction equation
[F:1][C:2]1[CH:17]=[C:16]([N+:18]([O-])=O)[C:15]([F:21])=[CH:14][C:3]=1[C:4]([NH:6][CH:7]1[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]1)=[O:5]>[Pd].CO>[NH2:18][C:16]1[C:15]([F:21])=[CH:14][C:3]([C:4]([NH:6][CH:7]2[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]2)=[O:5])=[C:2]([F:1])[CH:17]=1

Participants

4

Reactant 1

HCID 671592162,5-difluoro-N-(1-methyl-4-piperidyl)-4-nitro-benzamide2×

Product 1

HCID 671592594-amino-2,5-difluoro-N-(1-methyl-4-piperidyl)benzamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2,5-difluoro-N-(1-methyl-4-piperidyl)-4-nitro-benzamide (Intermediate 60; 633 mg 2.1 mmol), 10% Palladium on Carbon (70 mg) and Methanol (50 mL) were combined and stirred at 25 )C under Hydrogen at 3 bar pressure for 16 hours.

Sources & evidence

ORD record
ord-7037770a2267469ebc4315d86e02670a
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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