HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-chloro-N-(1-methyl-4-piperidyl)-4-nitro-benzamide → 4-amino-3-chloro-N-(1-methyl-4-piperidyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-chloro-N-(1-methyl-4-piperidyl)-4-nitro-benzamide | HCID 68686719 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-amino-3-chloro-N-(1-methyl-4-piperidyl)benzamide | HCID 58015033 | — |
Reaction Steps
3-chloro-N-(1-methyl-4-piperidyl)-4-nitro-benzamide (Intermediate 80; 270 mg, 1 mmol), 10% Palladium on Carbon (30 mg) and Methanol (50 mL) were combined and stirred at 25 )C under Hydrogen at 5 bar pressure for 16 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709471B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-075308b15fe946b2b11499b8f6fe1c67 |
| Source note | uspto-grants-2010_05 |