Ethylamine → 3-(ethylamino)-N-methylpropanamide

N-methylacrylamide (ABCR: 851 mg, 10.00 mmol) and ethylamine (2 M in methanol, 10 mL, 20.00 mmol) were combined in a microwave reaction vessel, which was sealed and irradiated at 140° C. for 30 mins. The reaction mixture was allowed to cool and then loaded directly onto a 50 g SCX-2 cartridge, washing with methanol (100 mL) and eluting the desired product with 7 N methanolic ammonia (100 mL). Concentration under reduced pressure of product containing fractions gave the title compound as a clear oil (1.285 g; 99%)

1. customwas sealed
2. customirradiated at 140° C. for 30 mins
3. temperatureto cool
4. washwashing with methanol (100 mL)
5. washeluting the desired product with 7 N methanolic ammonia (100 mL)
6. concentrationConcentration under reduced pressure of product
7. additioncontaining fractions

ORD record

ord-3144ea589d6342d2b1d3c024862215ab

Source dataset

uspto-grants-2010_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07709471B2