反应详情

N-methylacrylamide (ABCR: 851 mg, 10.00 mmol) and ethylamine (2 M in methanol, 10 mL, 20.00 mmol) were combined in a microwave reaction vessel, which was sealed and irradiated at 140° C. for 30 mins. The reaction mixture was allowed to cool and then loaded directly onto a 50 g SCX-2 cartridge, washing with methanol (100 mL) and eluting the desired product with 7 N methanolic ammonia (100 mL). Concentration under reduced pressure of product containing fractions gave the title compound as a clear oil (1.285 g; 99%)

1. customwas sealed
2. customirradiated at 140° C. for 30 mins
3. temperatureto cool
4. washwashing with methanol (100 mL)
5. washeluting the desired product with 7 N methanolic ammonia (100 mL)
6. concentrationConcentration under reduced pressure of product
7. additioncontaining fractions