Isobutylamine → N-methyl-3-(2-methylpropylamino)propanamide

HRID 2234392Notes

Reaction equation

HRID 2234392 reaction equation
[CH3:1][NH:2][C:3](=[O:6])[CH:4]=[CH2:5].[CH2:7]([NH2:11])[CH:8]([CH3:10])[CH3:9]>CCO>[CH3:1][NH:2][C:3](=[O:6])[CH2:4][CH2:5][NH:11][CH2:7][CH:8]([CH3:10])[CH3:9]

Participants

4

Reactant 2

HCID 6558IsobutylamineHCID 14471Methylacrylamide

Product 1

HCID 61870051N-methyl-3-(2-methylpropylamino)propanamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-methylacrylamide (ABCR; 1 g, 11.75 mmol) was dissolved in EtOH (5 mL). Isobutylamine (Aldrich; 2.33 mL, 23.5 mmol) was added and stirred at ambient temperature in a stoppered flask over the weekend. The reaction was then transferred to a microwave reactor vessel and heated in a microwave for 10 minutes at 140° C. Solvents were evaporated in vacuo to give the title compound as a colourless liquid. (1.78 g, 96%)

Workup

  1. customThe reaction was then transferred to a microwave reactor vessel
  2. temperatureheated in a microwave for 10 minutes at 140° C
  3. customSolvents were evaporated in vacuo

Sources & evidence

ORD record
ord-82411b28683f417ba8c5c9fe60723ad4
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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