3-(cyclobutylamino)-N-methyl-propanamide → 3-[(5-bromo-2-chloro-pyrimidin-4-yl)-cyclobutyl-amino]-N-methyl-propanamide

HRID 2234395Notes

Reaction equation

HRID 2234395 reaction equation
C1(NCCC(NC)=O)CCC1.[Br:12][C:13]1[C:14]([N:20]([CH:27]([CH2:29][CH3:30])[CH3:28])[CH2:21][CH2:22][C:23]([NH:25][CH3:26])=[O:24])=[N:15][C:16]([Cl:19])=[N:17][CH:18]=1>>[Br:12][C:13]1[C:14]([N:20]([CH:27]2[CH2:28][CH2:30][CH2:29]2)[CH2:21][CH2:22][C:23]([NH:25][CH3:26])=[O:24])=[N:15][C:16]([Cl:19])=[N:17][CH:18]=1

Participants

3

Reactant 2

HCID 618619683-(cyclobutylamino)-N-methyl-propanamideHCID 866175713-[(5-bromo-2-chloro-pyrimidin-4-yl)-butan-2-yl-amino]-N-methyl-propanamide

Product 1

HCID 866175723-[(5-bromo-2-chloro-pyrimidin-4-yl)-cyclobutyl-amino]-N-methyl-propanamide

Procedure

Using 3-(cyclobutylamino)-N-methyl-propanamide—Intermediate 92 and analogous conditions to Intermediate 88 the title compound was obtained as a white solid (609 mg)

Sources & evidence

ORD record
ord-493d6c527da54a22b11b5aabb32b7d77
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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