HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Phenylpiperidine → 2,3-dihydro-7-methoxy-8-[5-(4-phenyl-1-piperidinyl)pentyloxy]cyclopenta[c][1]benzopyran-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 8-(5-bromopentyloxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927636 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 2,3-dihydro-7-methoxy-8-[5-(4-phenyl-1-piperidinyl)pentyloxy]cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927718 | 37% |
Reaction Steps
Method B (20 h at 80° C.); starting materials: 8-(5-bromopentyloxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 85) and 4-phenylpiperidine; yield 37%; fusion point 103°-105° C. (from isopropanol and TBME). Fumarate: method E; yield 94%; fusion point 176°-178° C. (from isopropanol and TBME).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-1c7274b96f0b47aa88e9a7f1d1e0c0ba |
| Source note | uspto-grants-1995_06 |