反应详情

温度

140 °C

N-methylacrylamide (ABCR; 500 mg, 5.87 mmol) and 3,5-dimethoxybenzylamine (Aldrich; 0.98 mL, 6.46 mmol) were dissolved in ethanol (4 mL) and heated in a microwave at 140° C. for 45 minutes. The mixture was poured onto a 20 g SCX-2 column, washed with methanol and eluted with 3.5N NH3 in methanol. The product fractions were evaporated to the title compound as a yellow oil (1.3 g, 88%).

1. additionThe mixture was poured onto a 20 g SCX-2 column
2. washwashed with methanol
3. washeluted with 3.5N NH3 in methanol
4. customThe product fractions were evaporated to the title compound as a yellow oil (1.3 g, 88%)