HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-Amino-5-chloro-2-fluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-amino-5-chloro-2-fluorobenzoate | HCID 68684306 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Amino-5-chloro-2-fluorobenzoic acid | HCID 68683933 | 105.8% |
Reaction Steps
4-Amino-5-chloro-2-fluorobenzoic acid tert-butyl ester (Intermediate 177; 3.0 g, 12.21 mmol) was dissolved in DCM (75 mL) and trifluoroacetic acid (25 mL) added. The mixture was stirred for 1 hour at room temperature and then concentrated to yield the title compound as a pale yellow solid (2.45 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709471B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-2da3fecb0778402494c1e84b9da10a2b |
| Source note | uspto-grants-2010_05 |