HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3R)-1-Methyl-3-PyrrolidinaMine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-tert-Butyl 1-methylpyrrolidin-3-ylcarbamate | HCID 45091942 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (3R)-1-Methyl-3-PyrrolidinaMine hydrochloride | HCID 53256048 | — |
Reaction Steps
tert-butyl N-[(3R)-1-methylpyrrolidin-3-yl]carbamate (Intermediate 185; 1.18 g, 5.67 mmol) was dissolved in 1,4-dioxane (10 mL) and 4M HCl in dioxane (10 mL) added. The mixture was stirred at room temperature for 1 hour and then concentrated to yield the title compound as a white hygroscopic solid (810 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709471B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-aef1212eac7d477da2f0730538cbdad5 |
| Source note | uspto-grants-2010_05 |