HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-methoxy-N-[(3R)-1-methylpyrrolidin-3-yl]-4-nitro-benzamide → 4-amino-3-methoxy-N-(1-methylpyrrolidin-3-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-methoxy-N-[(3R)-1-methylpyrrolidin-3-yl]-4-nitro-benzamide | HCID 68683036 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-amino-3-methoxy-N-(1-methylpyrrolidin-3-yl)benzamide | HCID 68684123 | 100% |
Reaction Steps
A solution of 3-methoxy-N-[(3R)-1-methylpyrrolidin-3-yl]-4-nitro-benzamide (Intermediate 188; 227 mg, 0.81 mmol) in methanol (25 mL) was hydrogenated using 10% Pd/C catalyst. Catalyst was filtered off and solvent evaporated to yield the title compound as a yellow gum (200 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709471B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-683e4ef4c211450a9676a7f0eac795d8 |
| Source note | uspto-grants-2010_05 |