N-(1-ethyl-4-piperidyl)-3-methoxy-4-nitro-benzamide → 4-amino-N-(1-ethyl-4-piperidyl)-3-methoxy-benzamide

HRID 2234460Notes

Reaction equation

HRID 2234460 reaction equation
NC1C=CC(C(NC2CCN(C)C2)=O)=CC=1OC.[CH2:19]([N:21]1[CH2:26][CH2:25][CH:24]([NH:27][C:28](=[O:40])[C:29]2[CH:34]=[CH:33][C:32]([N+:35]([O-])=O)=[C:31]([O:38][CH3:39])[CH:30]=2)[CH2:23][CH2:22]1)[CH3:20]>>[NH2:35][C:32]1[CH:33]=[CH:34][C:29]([C:28]([NH:27][CH:24]2[CH2:23][CH2:22][N:21]([CH2:19][CH3:20])[CH2:26][CH2:25]2)=[O:40])=[CH:30][C:31]=1[O:38][CH3:39]

Participants

3

Reactant 2

HCID 68681536N-(1-ethyl-4-piperidyl)-3-methoxy-4-nitro-benzamide2×HCID 686841234-amino-3-methoxy-N-(1-methylpyrrolidin-3-yl)benzamide

Product 1

HCID 580150934-amino-N-(1-ethyl-4-piperidyl)-3-methoxy-benzamide

Procedure

The title compound was prepared in quantitative yield by an analogous method to the preparation of Intermediate 187, on a 2 g scale utilising N-(1-ethyl-4-piperidyl)-3-methoxy-4-nitro-benzamide (Intermediate 191).

Sources & evidence

ORD record
ord-8f69364c5a0d432089c8a5d9111f677e
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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