N-(2-(dimethylamino)ethyl)-3-methoxy-4-nitrobenzamide → 4-amino-N-(2-(dimethylamino)ethyl)-3-methoxybenzamide

HRID 2234464Notes

Reaction equation

HRID 2234464 reaction equation
[NH2:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([NH:8][CH:9]2C[CH2:12][N:11]([CH3:14])[CH2:10]2)=[O:7])=[CH:4][C:3]=1[O:17][CH3:18].CN(C)CCNC(=O)C1C=CC([N+]([O-])=O)=C(OC)C=1>>[NH2:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([NH:8][CH2:9][CH2:10][N:11]([CH3:12])[CH3:14])=[O:7])=[CH:4][C:3]=1[O:17][CH3:18]

Participants

3

Reactant 2

HCID 68683674N-(2-(dimethylamino)ethyl)-3-methoxy-4-nitrobenzamide2×HCID 686841234-amino-3-methoxy-N-(1-methylpyrrolidin-3-yl)benzamide

Product 1

HCID 580150424-amino-N-(2-(dimethylamino)ethyl)-3-methoxybenzamide

Procedure

The title compound was prepared in quantitative yield by an analogous method to the preparation of Intermediate 187, on a 2 g scale utilising N-(2-dimethylaminoethyl)-3-methoxy-4-nitro-benzamide (Intermediate 195).

Sources & evidence

ORD record
ord-dc12879abc504c0aa8233db9f83ed216
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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