HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 22821826, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 1-(Chloromethoxy)-2-methoxyethane | HCID 77590 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methyl lithocholate | HCID 92880 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22821826 | HCID 22821826 | — |
Reaction Steps
Methyl lithocholate is dissolved in methylene chloride, and β-methoxyethoxymethyl chloride and diisopropylethylamine are added. The mixture is stirred for four hours, ether added and washed with water. After drying the solvents are evaporated, the residue dissolved in toluene and the 24-ester group reduced to the 24-alcohol group with Vitride. The 24-alcohol then is oxidized with chromium trioxide-pyridine and the 3α-(β-methoxyethoxymethoxy)-5β-cholane-24-aldehyde obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04354972 |
| Source dataset | uspto-grants-1982_10 |
| ORD ID | ord-56fa0286287b4e47be76810483ecb679 |
| Source note | uspto-grants-1982_10 |