HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-1-methylpiperidine → 4-amino-2-chloro-5-methoxy-N-(1-methyl-4-piperidyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-1-methylpiperidine | HCID 2737531 | — |
| Reactant | 4-amino-3-chloro-N-(1-ethyl-4-piperidyl)benzamide | HCID 64321494 | — |
| Reactant | 4-Amino-2-chloro-5-methoxybenzoic acid | HCID 67003505 | — |
| Product | 4-amino-2-chloro-5-methoxy-N-(1-methyl-4-piperidyl)benzamide | HCID 68685668 | — |
Reaction Steps
The title compound was prepared by an analogous method to the preparation of Intermediate 212, on a 3.06 mmol scale utilising 4-amino-2-chloro-5-methoxy-benzoic acid (Intermediate 217; 617 mg, 3.06 mmol) and 1-methylpiperidin-4-amine (Fluorochem; 385 mg, 3.37 mmol), as an off-white solid (845 mg, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709471B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-a7e05c2002cd435eb919068f36d86de1 |
| Source note | uspto-grants-2010_05 |