HRID2234489

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN1C(=O)CCN(C2CCCC2)c2nc(Nc3cc(F)c(C(=O)OC(C)(C)C)cc3Cl)ncc21

HCID68684234

未命名化合物

HCID86617590

未命名化合物

PRODUCTS

生成物

HCID68684306

未命名化合物

结构：CN1C(=O)CCN(C2CCCC2)c2nc(Nc3c(Cl)cc(C(=O)OC(C)(C)C)c(F)c3Cl)ncc21

HCID86617589

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by an analogous method to the preparation of Intermediate 220, utilising tert-butyl 4-amino-3,5-dichloro-2-fluoro-benzoate (Isolated as a by-product during the preparation of Intermediate 177; 236 mg, 0.45 mmol), as an off-white solid (180 mg, 87%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1e6b077987ed47f8bfe8b159a9bc9e37
来源数据集: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07709471B2
来源说明: uspto-grants-2010_05

反应 SMILES

[Cl:1][C:2]1[C:3]([NH:16][C:17]2[N:27]=[C:26]3[C:20]([N:21]([CH3:34])[C:22](=[O:33])[CH2:23][CH2:24][N:25]3[CH:28]3[CH2:32][CH2:31][CH2:30][CH2:29]3)=[CH:19][N:18]=2)=[CH:4][C:5]([F:15])=[C:6]([CH:14]=1)[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8].[NH2:35][C:36]1[C:48]([Cl:49])=[CH:47][C:39]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])=[C:38]([F:50])[C:37]=1Cl>>[Cl:49][C:4]1[C:5]([F:15])=[C:6]([CH:14]=[C:2]([Cl:1])[C:3]=1[NH:16][C:17]1[N:27]=[C:26]2[C:20]([N:21]([CH3:34])[C:22](=[O:33])[CH2:23][CH2:24][N:25]2[CH:28]2[CH2:32][CH2:31][CH2:30][CH2:29]2)=[CH:19][N:18]=1)[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8].[C:43]([O:42][C:40](=[O:41])[C:39]1[CH:47]=[C:48]([Cl:49])[C:36]([NH2:35])=[CH:37][C:38]=1[F:50])([CH3:46])([CH3:44])[CH3:45]