反应详情

N-(1-methyl-4-piperidyl)-7-nitro-benzo[1,3]dioxole-4-carboxamide (Intermediate 224; 290 mg, 0.94 mmol) was suspended in methanol (50 mL) and the system purged with nitrogen. 10% Pd/C (30 mg) was added and the mixture stirred under a hydrogen atmosphere for 2 hours. The catalyst was filtered off and the filtrate evaporated to give the title compound as a white solid (249 mg, 96%).

1. customthe system purged with nitrogen
2. addition10% Pd/C (30 mg) was added
3. filtrationThe catalyst was filtered off
4. customthe filtrate evaporated