HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Pyrrolidineethanamine → 4-amino-2,5-difluoro-N-(2-pyrrolidin-1-ylethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Pyrrolidineethanamine | HCID 1344 | — |
| Reactant | 4-amino-2,5-difluoro-N-[(3R)-1-methylpyrrolidin-3-yl]benzamide | HCID 68682472 | — |
| Product | 4-amino-2,5-difluoro-N-(2-pyrrolidin-1-ylethyl)benzamide | HCID 68682856 | — |
Reaction Steps
The title compound was prepared by an analogous method to the preparation of Intermediate 229, on a 5.77 mmol scale utilising 2-pyrrolidin-1-ylethanamine (Aldrich; 725 mg, 6.35 mmol), as a beige solid (648 mg, 42%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709471B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-cd1fe32b89bb4d00af61da4aed2c8ad0 |
| Source note | uspto-grants-2010_05 |