HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 4-amino-N-[(3R)-1-ethylpyrrolidin-3-yl]-3-methoxy-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2486-69-3 | HCID 288057 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | (3R)-1-ethylpyrrolidin-3-amine | HCID 51663642 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-amino-N-[(3R)-1-ethylpyrrolidin-3-yl]-3-methoxy-benzamide | HCID 68685498 | — |
Reaction Steps
To a solution of 4-amino-3-methoxybenzoic acid (Aldrich; 424 mg, 2.54 mmol) and (3R)-1-ethylpyrrolidin-3-amine (Intermediate 246; 312 mg, 2.73 mmol) in DMF (10 mL) was added DIPEA (1.4 ml, 8.04 mmol). The resultant solution was treated with HATU (1.21 g, 3.18 mmol) and stirred, under nitrogen, at ambient temperature overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709471B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-637585bed9cf47c88c084a6732adfd7e |
| Source note | uspto-grants-2010_05 |