反应详情

温度

3 °C

To a stirred solution of 10-chloro-2-cyclopentyl-4,4-diethyl-2,6,9,11-tetrazabicyclo[5.4.0]undeca-7,9,11-trien-5-one (Intermediate 251; 2.5 g, 7.76 mmol) in DMA (50 mL) under nitrogen was added methyl iodide (0.627 mL, 10.0 mmol). The mixture was cooled on an ice/water bath to 3° C., and sodium hydride (60% mineral oil dispersion; 0.567 g, 11.8 mmol) added in one portion. The reaction mixture was stirred on the ice/water bath for 1 hour before warming to room temperature and the reaction stirred for 4 hours. The reaction mixture was evaporated to dryness to afford a black solid, which was quenched with saturated aqueous NH4Cl solution (50 mL), extracted with DCM (3×100 mL), dried and solvent removed in vacuo to yield a black solid which was purified on a silica column eluting with DCM. The obtained solid was added to a diethyl ether and sonicated and the resultant material filtered and dried to yield the title compound as an off white solid (2.1 g, 80%).

1. temperaturebefore warming to room temperature
2. customThe reaction mixture was evaporated to dryness
3. customto afford a black solid, which
4. customwas quenched with saturated aqueous NH4Cl solution (50 mL)
5. extractionextracted with DCM (3×100 mL)
6. customdried
7. customsolvent removed in vacuo
8. customto yield a black solid which
9. customwas purified on a silica column
10. washeluting with DCM
11. additionThe obtained solid was added to a diethyl ether
12. customsonicated
13. filtrationthe resultant material filtered
14. customdried