1,3-Diethyl 2-oxopropanedioate → HCID 70549630, compound

HRID 223451Notes

Reaction equation

HRID 223451 reaction equation
O=C(C(OCC)=O)C(OCC)=O.[Br:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][C:23]=1[Br:24])[N:20]=[C:19]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[C:18](=[O:30])[NH:17]2>C(O)C>[Br:13][C:14]1[C:23]([Br:24])=[CH:22][C:21]2[C:16](=[N:17][C:18](=[O:30])[CH:19]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[N:20]=2)[CH:15]=1

Participants

4

Reactant 2

HCID 691051,3-Diethyl 2-oxopropanedioateHCID 6320219HCID 6320219, compound

Product 1

HCID 70549630HCID 70549630, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4,5-Dibromo-o-phenylaminediamine was cyclized to the corresponding quinoxaline carboxylic acid ester by the procedure of Example 1 utilizing 4.1 g. of the diamine and 2.7 g. of diethyl ketomalonate in 75 ml. of anhydrous ethanol. Ethyl 6,7-dibromo-3,4-dihydro-3-oxo-2-quinoxaline carboxylate thus prepared melted at 235°-236° C. (yield=3.9 g.).

Sources & evidence

ORD record
ord-66eef134c6a4447e8f479d844c04f6d6
Source dataset
uspto-grants-1982_10
Patent number
US04355030

Reaction notes

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