反应详情

Methyl1-cyanocyclopentane-1-carboxylate (Intermediate 260; 6 g, 39.2 mmol) in acetic acid (70 mL) was hydrogenated using Pt O2 (600 mg) as a catalyst at room temperature under 4 Bar pressure for 4 hours. The reaction mixture was filtered and concentrated. The residue was taken up in methanol and absorbed on to an SCX column (3×50 g), which was then washed with methanol and eluted with ammonia in methanol. Concentration of product containing fractions yielded the title compound as a pale yellow liquid (6.18 g, 100%).

1. customat room temperature
2. customfor 4 hours
3. filtrationThe reaction mixture was filtered
4. concentrationconcentrated
5. customabsorbed on to an SCX column (3×50 g), which
6. washwas then washed with methanol
7. washeluted with ammonia in methanol
8. additionConcentration of product containing fractions