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HRID22346

反应详情

EQUATION

反应方程式

HRID 22346 的结构方程式

REACTANTS

反应物

4
结构：CCO
HCID702

Ethanol

C2H6O

结构：Cc1cccc(N2CCNCC2)c1C
HCID70541

1-(2,3-Xylyl)piperazine

C12H18N2

结构：O=C([O-])/C=C/C(=O)[O-]
HCID5460307

Fumerate

C4H2O4-2

结构：COc1cc2oc(=O)c3c(c2cc1OCCCOS(C)(=O)=O)CCC3
HCID19927662

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc2oc(=O)c3c(c2cc1OCCCN1CCN(c2cccc(C)c2C)CC1)CCC3
HCID19927667

未命名化合物

收率 84%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Method B (20 h at 60° C.); starting materials: 2,3-dihydro-8-[3-(methanesulfonyloxy)propoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one (example 82) and 1-(2,3-dimethylphenyl)-piperazine; yield 84%; fusion point 164°-166° C. (from ethanol). Fumarate: method E; yield 94%; fusion point 235°-237° C. (from acetone).

WORKUP

后处理

  1. customMethod B (20 h at 60° C.)